PPI


Have you or a loved one suffered from a kidney injury after taking Nexium, Prilosec, or Previcid? You may be entitled to compensation.

Have you or a loved one suffered from a kidney injury after taking Nexium, Prilosec, or Previcid? You may be entitled to compensation.

Link to our form. See if you qualify

The Nexium and Prilosec lawsuits claim that proton pump inhibitors cause an increased risk of kidney and renal failure. As of October 2018, more than 2,300 lawsuits have been filed in federal court against the manufacturers of Nexium & Prilosec.

Why Are Nexium & Prilosec Lawsuits Being Filed?

More than 4,000 lawsuits have been filed against the manufacturers of Nexium and Prilosec by individuals who have suffered injuries as a result of taking these two proton pump inhibitor (PPI) medications. The lawsuits are presently combined before a federal judge in New Jersey where all of the national discovery and evidence gathering is taking place.

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The Key Legal Issue

The manufacturers of Nexium and Prilosec failed to warn doctors and patients that use of its medication could cause kidney and renal failure, including acute interstitial nephritis (AIN).

In the court filings, lawyers argue the following:

  • Nexium and Prilosec are defective and unreasonably dangerous.
  • The manufacturers (including AstraZeneca, Proctor & Gamble, and Pfizer) were negligent in the production of the drug.
  • The manufacturers failed to properly test the medication, and failed to warn doctors and patients of certain risks.
  • The manufacturers concealed evidence of the dangers from the government and the public, and misrepresented the safety of the drug in its marketing material.

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Nexium and Prilosec Injuries & Side Effects

The most serious potential side effects caused through the use of Nexium & Prilosec are strokes, bone fractures, acute kidney injury (AKI), renal failure, and heart damage.

People who take multiple daily doses for a long period of time (a year or longer), especially those 50 years of age or older, have an increased risk of fractures of the hip, wrist, and spine. Additionally, people who use the drugs appear to have a 20-50% higher risk of chronic kidney disease compared with nonusers, and a 20-30% increased risk for stroke.

Nexium & Prilosec User Warning

Nexium and Prilosec users "are at increased risk for heart attack, stroke and renal failure,” says Dr. John P. Cooke, Houston Methodist Research Institute.

It’s very important to tell your doctor if you experience any of the following problems: (i) kidney disease; (ii) osteoporosis; (iii) low bone mineral density (osteopenia); (iv) numbness in the face, arm or leg; (v) confusion or trouble speaking; (vi) loss of vision; (vii) dizziness; (viii) difficulty walking; (ix) severe headache; or (x) low levels of magnesium in your blood.

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Cardiovascular diseases and heart attacks

According to a large clinical trial called PLOS ONE, the use of Nexium and other PPIs has been associated with an estimated increase in heart attack risk of 16-21%. These drugs can reduce the production of a substance that protects blood vessels. The internal lining of the vessels is then damaged, increasing the formation of dangerous blood clots and other cardiovascular diseases.

Chronic kidney disease

PPIs are linked with a 20 to 50 percent higher risk of chronic kidney disease (CKD), as demonstrated by a large study published in the JAMA Internal Medicine journal. The risk is higher in patients who took higher doses of these medications. CKD causes a gradual loss of kidney function that may also lead to renal failure.

Symptoms of Chronic Kidney Disease

Symptoms of CKD include: (1) buildup of fluid in the lungs; (2) difficulty urinating; (3) electrolyte imbalances; (4) extreme fatigue; (5) heartbeat abnormalities; (6) high blood pressure; (7) nausea, vomiting or loss of appetite; and (8) swelling in the legs, ankles or feet.

Ischemic stroke

An ischemic stroke occurs when the flow of blood and oxygen to the brain is reduced, causing the brain cells and tissue to die. PPIs are linked to a 20-30% increased risk of strokes depending upon the dosage the person is taking per day.

Gastric tumors, bone fractures and anemia

Nexium and Prilosec do more than just reduce gastric acid, they also reduce the secretion of several other substances produced by stomach cells. These specific substances are required for the proper absorption of important nutrients such as Vitamin C, Vitamin B12, calcium, and magnesium.

Long-term use of PPIs has been associated with iron deficiency anemia, hypomagnesemia, and pernicious anemia. The use of PPIs for extended periods may also reduce bone strength, increasing the  risk of hip, spine, and wrist fractures.

PPIs also indirectly increase the production of other substances such as gastrin. Hypergastrinemia has been associated with an increased risk of gastric tumors as well as with other cancer malignancies in patients affected by gastroesophageal reflux disease (GERD).

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Pneumonia, diarrhea and systemic infections

Proper gastric acid secretion is critical to our health. PPIs reduce acid secretion by up to 99%, which is much more than is usually required by most patients, especially if these drugs are taken for extended periods of time.

Hydrochloric acid is, in fact, a barrier to sterilize the food we eat, killing most microbes such as bacteria and viruses. Without stomach acid, patients are at a greater risk of serious infections including Clostridium difficile enteritis, diarrhea, and pneumonia.

Risk of Dementia

A study published in the journal JAMA Neurology showed that regular use of PPIs was linked with a 50% increased risk of dementia in elderly patients. Researchers analyzed data from 74,000 patients over a period of 7 years, and explained that in those countries where PPIs are available as over-the-counter medications (such as the United States), the risk may be even higher.

Compensation in Nexium & Prilsoec Lawsuits

We are representing individuals who have suffered kidney or renal injuries as a result of using Nexium or Prilosec. If you have experienced these injuries, then we will be seeking the following damages for you:

  • Past and future medical expenses that result from your injuries.
  • Past and future pain and suffering (physical and mental) caused by the injuries, and the treatment and recovery process.
  • Past and future wage loss.
  • Past and future loss of earning capacity.
  • Past and future loss of enjoyment of life.
  • Punitive damages, if appropriate

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